The jam-packed heritage programme includes free performances, exhibitions, historic talks, guided walks and workshops.
It will take place over ten days from Friday 10th to Sunday 19th September and has been organised by Milton Keynes Council.
Key attractions opening their doors for free include Milton Keynes Museum, MK Gallery, Great Linford Manor Park, Westbury Arts Centre, Milton Keynes City Discovery Centre, The Stables Theatre and the Cowper & Newton Museum in Olney.
Cllr Robin Bradburn, MKC Deputy Leader and Cabinet Member for Culture, said: “Despite the challenges presented by the pandemic, it’s amazing that once again Heritage Open Days organisations have come together to provide a fantastic number and quality of events during September, on a variety of heritage and cultural themes.
"This flagship heritage event really puts Milton Keynes on the map nationally and will provide exciting and safe activities that everyone can get involved with."
This year's theme is "Edible England" which encourages local people to head out on foraging walks across Milton Keynes.
A spokesperson for the event explained: "Come to the Old School House in Wolverton to enjoy Foodie Forest School and Hedgehog High Tea, sample the famous Buckinghamshire Clanger at the Old Bath House, head over to MK Museum for the annual Beer Festival or tuck into a cream tea as you listen to the sounds of Milton Keynes Brass."
Once again there are online activities as well as plenty of self-guided walks and trails.