The owner has said that redevelopment of the area and tough trading conditions are to blame.
The award-winning restaurant, near the train station, was battling against a number of events that led to the owner, Aki Rahman, making the final decision to close. He told MKFM: "The premises is due to be redeveloped and we were asked to hand back the lease following a dispute with the landlords.
"We've had a run of bad luck and it's felt that everything has been against us."
The Don was due to have its alcohol and late licence reviewed on Wednesday (3/6) after immigration officials claimed three people had been working there illegally last December.
Milton Keynes Council's licensing subcommittee held a four-minute meeting to discuss the matter, with licensing officer Ed Fisher saying that Mr Rahman had "surrendered" the licence on Monday (1/6). The meeting was cut short when the three councillors had "nothing to decide".
No further action was taken against Mr Rahman following his further defence that he had been feeding many homeless people in the area.
He added: "Everyone knows we do a lot for the homeless in Milton Keynes, the restaurant has supported no end of charities and sponsored local sports teams. We have never been in trouble in five years."
In 2015, The Don had been featured in the national press after Mr Rahman applied to deliver curries by drone.
The popular Indian Restaurant is expected to reopen in a new location towards the end of summer 2020 when trading conditions improve, and when all restaurants are allowed to open fully.
Additional reporting by Local Democracy Reporter - David Tooley
