Cafe Rouge in Milton Keynes will be closing permanently as the owners of the chain enter administration.
Casual Dining Group, who own Cafe Rouge, Bella Italia and Las Iguanas, have called in administrators and will cut more than 1,900 jobs as well as closing 91 restaurants across the UK.
The company have blamed the "extreme operating environment" with the coronavirus lockdown.
Cafe Rouge at The Centre MK in Milton Keynes is one of the 91 sites which will close down for good.
However, the two Bella Italia sites (at the Theatre District and Stadium MK) as well as Las Iguanas at The Hub Milton Keynes will remain open.
Chief executive James Spragg said: "After reviewing all our options with advisors, it became clear that we needed to take this action in order to protect the business and secure the best possible future for Casual Dining Group as we look to conclude a potential sale."
Joint administrator Clare Kennedy of Alix Partners said: "Our immediate priorities are to assist those whose employment has been affected by today’s announcement and to secure a sale for the group in order to protect jobs and provide the group’s much-loved brands with a sustainable platform for the future."
The closures represent more than a third of the company's 250 UK sites around the UK. It leaves around 4,050 employees still in work.