There is further strike action planned for Thursday 15th and Saturday 17th September.
Passengers are set to face more disruption at Milton Keynes Central with ASLEF and RMT unions set to take strike action on Thursday 15th and Saturday 17th September.
The TSSA union have also planned strike action from Monday 26th to Tuesday 27th September.
It follows multiple previous wide scale strikes across the country over pay disputes.
Mick Whelan, general secretary of Aslef, said: "We regret that, once again, passengers are going to be inconvenienced, because we don't want to go on strike - withdrawing our labour, although a fundamental human right, is always a last resort for a trade union - but the train companies have forced our hand.
"They want train drivers to take a real-terms pay cut - to work just as hard this year as last, but for 10% less.
"Because inflation is now in double figures and heading higher - much higher, according to some forecasts - and yet the train companies have offered us nothing.
"And this for train drivers who kept Britain moving - key workers and goods around the country - throughout the pandemic and who have not had an increase in salary since 2019."
Avanti West Coast, Chiltern Railways, CrossCountry, Greater Anglia, Great Western Railway, Hull Trains, LNER, London Overground, Northern Trains, Southeastern, TransPennine Express and West Midlands Trains are set to be affected.
It comes as Arriva bus workers have gone on strike today in Milton Keynes,
