Thames Valley Police is appealing for witnesses to a road traffic collision on the A421 near Great Horwood.
At 7.10pm on Monday (27/11), a green Vauxhall Mokka and a yellow Mercedes-Benz Sprinter were involved in a head-on collision near Briars Bank Farm, between the roundabout for the B4033 and Warren Road.
Both the Vauxhall driver, a man in his thirties, and the other driver, a man in his fifties, suffered life-changing injuries and were taken to hospital, where they remain in stable conditions.
No one else was injured and no one else is being sought in relation to the collision.
Investigating officer PC Lewis Harratt, of the Joint Operations Roads Policing Unit, said: “I am appealing for any witnesses to this collision, which resulted in two men suffering life-changing injuries, to please come forward.
“Also, if you were driving in the area around the time of the collision and have a dash-cam, please check your recording in case it has captured something that could assist us and get in touch if you have.
“Anyone with information or footage should call 101 or make a report on our website, quoting reference number 43230533947.”