It is all part of the smart motorway works taking place on the M1 near Milton Keynes.
A spokesperson for National Highways said: "Roadworks affect all journeys which is why it is important they are completed as quickly and safely as possible. Our overnight closures are under constant review and we aim to open the road earlier than the times displayed wherever possible.
"Please be considerate of residents living along the diversion routes when travelling during these closures. Closures can only be installed once traffic flows are at their lowest."
Drivers are being warned to plan ahead when travelling, as it may disrupt late or early journeys.
Southbound
Tuesday 10 May for 3 nights
9pm - 6am, Junction 16 - Junction 15 full carriageway closure
Friday 13 May
9pm- 6am, Junction 15a - Junction 15 full carriageway closure.
Junction 16 - 15a, Lanes 3 and 2 closed.
Junction 15 - 14, Lanes 1 and 2 closed, Junction 15a entry slip closed.
You can find out more and keep up to date here.
